Here, the clinical manifestations, pathogenesis, relationship between Adie's pupil and diseases, and differential diagnosis of Adie's pupil are reviewed. Differential diagnosis between Adie's pupil, oculomotor nerve palsy, anticholinergic drug overdose, Argyll-Robertson pupil, and congenital mydriasis need to be identified by the physician. It is essential for clinicians to improve their understanding of the disease to avoid misdiagnosis. Pilocarpine can be used to treat ophthalmologic symptoms, such as blurred vision, for which patients might visit an ophthalmologist or neurologist. The ophthalmological symptoms and pupil abnormalities can disappear after active treatment of the primary disease. Through a literature review, we found that Adie's pupil is mainly associated with infectious diseases, most commonly syphilis, followed by immune diseases and paraneoplastic syndromes. The pathogeneses of Adie's pupil are complex, some of which are insidious and lack corresponding specific diseases. ![]() Although historically associated with neurosyphilis, Argyll Robertson pupil. First described in 1869 by Dr Argyll Robertson in a case series of 5 patients with tabes dorsalis, the pupillary abnormality is characterized by small, irregularly shaped pupils that accommodate but do not react to light. The pupil on the affected side is sensitive to low concentrations of pilocarpine. Bottom, Papillary constriction to accommodation. Language Label Description Also known as English: Argyll Robertson pupil. If this is the case you will need to decide which is the predominant lesions and bear in mind that even if the absence of a. Argyll Robertson phenomenon or pupil, nonsyphilitic Argyll Robertson pupil, atypical Atypical Argyll-Robertson pupil (disorder) Atypical Argyll-Robertson pupil edit. Mixed valve disease: Listen for an accompanying ESM radiating to the carotids of aortic sclerosis. The direct and indirect light reflection from the pupil on the affected side disappears. Syphilis: Argyll robertson pupil (small, irregular, depigmentation of the iris, accommodates but does not react to light). ![]() The pupil of the affected side is significantly larger than that on the healthy side. Most patients have unilateral eye involvement. Adie's pupil, also called tonic pupil, is mainly seen in young women.
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